When Luka Kriszanac, a spirited 29-year-old, returned to Penn Medicine, the atmosphere was filled with warmth and joy as he reunited with his surgical team. This heartfelt moment is even more astonishing considering that Luka had just undergone a groundbreaking double hand transplant, a remarkable achievement in the field of medicine.

Luka is among a select group of five individuals who have received this extraordinary procedure at Penn Medicine, renowned for its pioneering work in hand transplantation. His journey began with a severe case of strep throat that developed into a life-threatening sepsis infection when he was just 12 years old in Switzerland. Tragically, this led to the amputation of both his legs and hands.

Reflecting on his incredible transformation, Luka shared, “Regaining hands after 17 years, I don’t think there is a bigger dream than that.” He expressed immense gratitude to the family of his donor, emphasizing how their generosity has forever changed his life and the lives of his loved ones.

In 2018, after learning about Penn’s innovative hand transplant program, Luka began collaborating with a dedicated team to assess his eligibility for the procedure. Under the guidance of L. Scott Levin, Chair Emeritus of the Department of Orthopedic Surgery, and Benjamin Chang, the associate chief of plastic surgery, Luka embarked on a hopeful journey that would ultimately lead him to a suitable donor.

The process of finding a match is no small feat, as it requires compatibility in genetic and blood profiles, muscle and bone density, skin tone, and age. After navigating delays due to pandemic-related restrictions, the Gift of Life program finally connected Luka with a donor in 2024.

In a momentous overnight surgery, a skilled team came together in a collaborative effort that lasted 10 hours, with one group preparing Luka and another working on the donor. This remarkable event showcases the incredible advancements in surgical techniques and the compassionate spirit of those involved in transplantation.

When Luka awoke from surgery, he was filled with amazement at the possibilities before him. Through dedicated rehabilitation, he has regained the ability to perform everyday tasks like resting his head on his hands, adjusting his glasses, typing on his smartphone, and even savoring a meal. He has also begun to experience sensations like temperature, which adds to his newfound joy.

Although Luka will continue to engage with the Penn team for ongoing support and monitoring, his bond with these healthcare professionals is a testament to the lasting relationships formed through such life-altering procedures. Reflecting on this commitment, Levin remarked, “When we take this on, we are their doctors and caregivers forever.” This dedication extends across the entire medical team, ensuring that every patient receives the care they need throughout their journey.

As Luka made his first visit back to Philadelphia in June, the air was filled with a sense of gratitude and happiness. His story is not just one of medical triumph but also a reminder of the profound impact of compassion and community in transforming lives.